AVecGen Showcases Groundbreaking Malaria Research at Gordon Conferences in Barcelona
In May 2025, the AVecGen team proudly participated in the prestigious Malaria Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) held in Barcelona, Spain. These internationally renowned scientific gatherings brought together leading experts committed to advancing the frontiers of malaria research.
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Gadji Mahamat: Unveiling Genomic Insights into Insecticide Resistance
Gadji Mahamat, AVecGen Bioinformatic lead, made a remarkable contribution as a speaker at both the GRS and GRC. On May 24, during the GRS, Gadji presented compelling findings on the genomic evolution and insecticide resistance of Anopheles funestus—one of the most dangerous malaria vectors—with a focus on Cameroon. He revealed groundbreaking genomic evidence showing the emergence and rapid spread of key pyrethroid resistance loci within just seven years in mosquito populations from Mibelong, Cameroon.
His research highlighted how temporal selection pressures have driven the fixation of missense mutations and structural variants, particularly in major cytochrome P450 genes. These findings underscore the urgent need for functional validation of these variants and the development of cost-effective genomic surveillance strategies across the country.
On May 27, at the GRC, Gadji expanded on his earlier work, presenting further evidence of the rapid dissemination of major resistance loci, including rp1 and CYP9. He emphasized the complex interplay of genetic factors that enable mosquitoes to survive even high doses of insecticides. His presentation stressed the importance for Cameroon’s National Malaria Control Programme to integrate resistance dynamics into the design and implementation of vector control strategies.
Prof. Charles Wondji: Tackling the Genetic Basis of Resistance Escalation
On May 28, Prof. Charles Wondji, AVecGen’s Principal Investigator, delivered an insightful talk titled “Genetic Basis of Resistance Escalation to Insecticides in Malaria Vectors in Africa.” He addressed the growing challenges posed by insecticide resistance, shared recent scientific advances, and introduced innovative diagnostic tools aimed at preserving the effectiveness of key interventions such as insecticide-treated bed nets.
This participation at the Gordon Conferences marks a significant milestone for AVecGen and CRID, showcasing their leadership in cutting-edge malaria research and their commitment to developing sustainable solutions for vector control in Africa.
