This will involve the implementation of a comprehensive and sustainable sequencing facility that integrates multiple platforms to support cutting-edge genomic research and innovation. Central to this initiative is the setup of an Illumina short-read sequencing facility, anchored by the installation of the NovaSeq 6000 system at CRID, which will enable high-throughput, high-accuracy sequencing for a wide range of applications. Complementing this, the project will introduce a long-read sequencing platform using the Oxford Nanopore PromethION system, which is particularly suited for resolving complex genomic regions and structural variants. This platform will also support long-read transcriptomics, enhancing the characterization of alternative splicing events and transcript diversity. To provide a full spectrum of sequencing services, the project will implement a Sanger sequencing service, ideal for targeted sequencing and validation tasks. Underpinning all these efforts is the development of a business case to ensure the long-term sustainability of the facility, including strategies for cost recovery, service delivery, and regional engagement. Together, these components will create a versatile, future-ready sequencing hub capable of advancing genomics research, training, and diagnostics across diverse scientific and clinical domains.